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In this issue:

Massive Transfusion and Control of Hemorrhage in the Trauma Patient

4 • President’s Message
James Gordon Cain, MD

6 • Introduction
Charles E. Smith, MD, FRCPC, Andrew D. Rosenberg, MD, and Christopher M. Grande,MD, MPH

Section I: ETIOLOGY & PATHOPHYSIOLOGY

7 • Trauma, A Disease of Bleeding
Thomas M. Scalea, MD

12 • Pathophysiology of Traumatic Shock
Richard P. Dutton, MD, MBA

Section II: THERAPEUTIC STRATEGIES

16 • Surgical Perspectives to Control Bleeding in Trauma
Brian R. Plaisier, MD

24 • Hemostatic Drugs in Trauma and Orthopaedic Practice
Kathy Satkurunath, FRCA, and David Royston, FRCA

29 • Anemia, Erythropoietin, and the Trauma Patient
Aryeh Shander, MD, FCCM, FCCP, Nisha R. Gandhi, MD, FCCP, and Lawrence T. Goodnough, MD

35 • Cell Salvage in Trauma
Fraser D. Rubens MD, MSc, FRCSC, Aneil Mujoomdar, MD, FRCSC, and Homer C. Tien, MD, FRCSC

Section III: TRANSFUSION: CLINICAL PRACTICE

42 • Fluid and Blood Therapy in Trauma
Maxim Novikov, MD, and Charles E. Smith, MD, FRCPC

57 • Fluid Choice for Resuscitation in Trauma
Joachim Boldt, MD, PhD

66 • Trauma Surgery and Transfusion Options
Jonathan H. Waters, MD

71 • Priniciples of Fluid and Blood Warming in Trauma
Charles E. Smith, MD, FRCPC, and Karl Wagner, MD

Section IV: NEW HORIZONS IN SYNTHETIC BLOOD SUBSTITUTES

80 • Hemoglobin-Based Oxygen Carriers
John J. Como, MD, and Mark A. Malangoni, MD

86 • Current Artificial Oxygen Carriers and Their Potential Role in the Management of Hemorrhage
Armin Schubert, MD, MBA

CME

96 • CME Questions